Kinetics of myosin node aggregation into a contractile ring

We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that bands of nodes condense into rings when the range of node interactions is larger than the width of the band. Wide bands are unstable to clump...

Full description

Saved in:

Bibliographic Details
Published in:	Physical review letters Vol. 105; no. 4; p. 048102
Main Authors:	Ojkic, Nikola, Vavylonis, Dimitrios
Format:	Journal Article
Language:	English
Published:	United States 20-07-2010
Subjects:	Computer Simulation Cytokinesis Kinetics Monte Carlo Method Myosins - metabolism Schizosaccharomyces - cytology Schizosaccharomyces - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that bands of nodes condense into rings when the range of node interactions is larger than the width of the band. Wide bands are unstable to clump formation due to Poisson density fluctuations. We derive expressions for node kinetics and times for ring vs clump formation and test them using numerical simulations. These results suggest clump formation mechanisms in mutant cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-9007 1079-7114
DOI:	10.1103/PhysRevLett.105.048102