The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells

• Published in: ChemMedChem Vol. 16; no. 2; pp. 420 - 428
• Main Authors: Barros‐Nepomuceno, Francisco Washington A., Araújo Viana, Daniel, Pinheiro, Daniel Pascoalino, Cássia Evangelista de Oliveira, Fátima, Magalhães Ferreira, Jamile, R. de Queiroz, Maria Goretti, Ma, Xinghua, Cavalcanti, Bruno Coêlho, Pessoa, Claudia, Banwell, Martin G.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 19-01-2021
• Subjects: Alkaloids; Anticancer properties; Antiinfectives and antibacterials; Antitumor activity; Cyclophosphamide; Genotoxicity; Hematology; In vivo methods and tests; Sarcoma; Surgical implants; Tumor cells
• ISSN: 1860-7179; 1860-7187
• DOI: 10.1002/cmdc.202000387

The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T‐J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including hematological, biochemical, histopathological, genotoxic and clastogenic assays. As a result it was established that this alkaloid has a significant therapeutic window and effectively reduces tumor growth (by 40 % and 79 % at doses of 10 and 20 mg/kg/day, respectively). In this regard it displays similar antitumor activity to the anticancer agent cyclophosphamide and alters animal weight in an analogous manner.
Antitumor marine molecules: The alkaloid tambjamine J (T‐J) has been evaluated in vivo for its cytotoxic effects against sacrcoma 180 tumor cells implanted in mice. T‐J proved as efficacious as the clinically deployed nitrogen mustard cyclophosphamide while displaying reduced genotoxic and mutagenic effects.