Design, Synthesis, and SAR Studies of Mefloquine-Based Ligands as Potential Antituberculosis Agents

Potential new tuberculosis treatment: Mefloquine (1), an antimalarial drug with simple, yet interesting structural features has been found to be active against Mycobacterium tuberculosis. Thus, this molecule is a good candidate as a lead compound in the search for new TB drugs. The design and synthe...

Full description

Saved in:

Bibliographic Details
Published in:	ChemMedChem Vol. 1; no. 6; pp. 593 - 597
Main Authors:	Jayaprakash, Sarva, Iso, Yasuyoshi, Wan, Baojie, Franzblau, Scott G., Kozikowski, Alan P.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 12-06-2006 WILEY‐VCH Verlag
Subjects:	alkylation amination Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology hydrazones Ligands mefloquine Mefloquine - analogs & derivatives Mefloquine - chemical synthesis Mefloquine - chemistry Mefloquine - pharmacology Mycobacterium tuberculosis Structure-Activity Relationship tuberculosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Potential new tuberculosis treatment: Mefloquine (1), an antimalarial drug with simple, yet interesting structural features has been found to be active against Mycobacterium tuberculosis. Thus, this molecule is a good candidate as a lead compound in the search for new TB drugs. The design and synthesis of mefloquine analogues is described, and biological data against the TB organism are also presented.
Bibliography:	ArticleID:CMDC200600010 istex:26343BC005363D3B17481AEB55014D21C7199657 ark:/67375/WNG-63HWXZZG-8 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.200600010