In vitro antioxidant, antibacterial, and antihyperlipidemic potential of ethanolic Avicennia marina leaves extract supported by metabolic profiling

• Published in: Environmental science and pollution research international Vol. 28; no. 21; pp. 27207 - 27217
• Main Authors: Yassien, Eman E., Hamed, Moaz M., Abdelmohsen, Usama Ramadan, Hassan, Hanaa M., Gazwi, Hanaa S. S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2021; Springer Nature B.V
• Subjects: Antiinfectives and antibacterials; Antioxidants; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Atorvastatin; Avicennia marina; Dexamethasone; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Free radicals; High density lipoprotein; Hyperlipidemia; Leaves; Lipid peroxidation; Lipids; Peroxidation; Plant extracts; Research Article; Salmonella; Scavenging; Steroids; Superoxide dismutase; Waste Water Technology; Water Management; Water Pollution Control; Atorvastatin; Dexamethasone; Antibacterial; LC-MS analysis; Avicennia marina
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-021-12496-7

This study aimed to examine the impact of ethanolic
Avicennia marina
(
A. marina
) leaves extract against seven pathogenic bacteria and the protective effect of this plant against hyperlipidemia caused by dexamethasone (DEX)-treated rats. Forty-eight male rats weighing between 150 and 200 g were randomly selected into six groups containing eight rats in each group. Moreover, in vitro antioxidant DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical scavenging activity, FRAP (ferric reducing antioxidant power), and ABTS assay were also analyzed for leaf extract. Results showed that the IC
50
values were observed as 193.9 ± 1.03 μg/mL, 340.29 ± 8.16 μM TE/mg, and 326.8 ± 6.14 μM TE/mg for DPPH, FRAP, and ABTS radical scavenging activities, respectively.
A. marina
leaves ethanolic extract exhibited higher activity against
Candida albicans
and
Bacillus subtilis
, moderate activity against
Salmonella typhimurium
, and
Vibrio damsel.
The administration of DEX resulted in significant (
P
< 0.05) increase in the levels of MDA concentration, TG, TC, LDL, LDH, and glucose but decreased significantly in HDL. Treatment with
A. marina
extract positively reversed the distorted lipid profile and peroxidation and improved MDA, GSH, NO, and SOD activities in DEX-administered rats. Histological investigation of liver tissue sections showed that the treatment with
A. marina
leaves extract moderate the fatty change caused by DEX. It is concluded that
A. marina
leaves extract improved the hypolipidemic property of DEX administration in comparison with standard treatment with atorvastatin.