Sublethal and lethal toxicity in juvenile Senegal sole ( Solea senegalensis) exposed to copper: A preliminary toxicity range-finding test

• Published in: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 61; no. 2; pp. 113 - 121
• Main Authors: Oliva, M., Garrido, M.C., Sales Márquez, D., González de Canales, M.L.
• Format: Journal Article
• Language: English
• Published: Munich Elsevier GmbH 01-03-2009; Elsevier
• Subjects: Animals; Biological and medical sciences; Copper; Copper Sulfate - toxicity; Dose-Response Relationship, Drug; Flatfishes - growth & development; Gills - drug effects; Gills - pathology; Histocytological Preparation Techniques; Histopathology; Investigative techniques, diagnostic techniques (general aspects); LC 50; Lethal Dose 50; Liver - drug effects; Liver - pathology; Medical sciences; Necrosis; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Solea senegalensis; Toxicity; Toxicity Tests - methods; Water Pollutants, Chemical - toxicity; Senegal; Africa; LC 50; Histopathology; Copper; Toxicity; Solea senegalensis; LC50; Anatomic pathology; Range finding; Mortality; Exploration
• ISSN: 0940-2993; 1618-1433
• DOI: 10.1016/j.etp.2008.06.001

Static bioassay test for acute toxicity of copper in Senegal sole juveniles (
Solea senegalensis) was conducted. The 96
h LC
50 value of metal was found to be 0.32
mg/L Cu. The intensity of histological alterations was increased gradually with the copper concentration and the exposure time. Numerous aneurysms, hypertrophy, hyperplasia and fusion of the lamellar epithelium in gills and a disorganization of the hepatic parenchyma and vacuolization in liver were common lesions in
S. senegalensis juveniles exposed to copper. The results of the study indicate the sensitivity of juvenile
S. senegalensis to copper (II), the persistence of sublethal effects and histology as a tool capable of revealing the sublethal effects of heavy metals on the environment and aquatic biota.