Prospective Randomized Trial of Docetaxel Versus Best Supportive Care in Patients With Non–Small-Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy

• Published in: Journal of clinical oncology Vol. 18; no. 10; pp. 2095 - 2103
• Main Authors: SHEPHERD, F. A, DANCEY, J, COUGHLIN, S, YONG KIM, BERILLE, J, RAMLAU, R, MATTSON, K, GRALLA, R, O'ROURKE, M, LEVITAN, N, GRESSOT, L, VINCENT, M, BURKES, R
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01-05-2000; Lippincott Williams & Wilkins
• Subjects: Adult; Aged; Antineoplastic Agents - therapeutic use; Antineoplastic Agents, Phytogenic - therapeutic use; Biological and medical sciences; Carboplatin - therapeutic use; Carcinoma, Non-Small-Cell Lung - drug therapy; Chi-Square Distribution; Cisplatin - therapeutic use; Disease Progression; Docetaxel; Female; Humans; Lung Neoplasms - drug therapy; Male; Medical sciences; Middle Aged; Paclitaxel - analogs & derivatives; Paclitaxel - therapeutic use; Palliative Care; Pneumology; Proportional Hazards Models; Prospective Studies; Quality of Life; Survival Analysis; Taxoids; Treatment Outcome; Tumors of the respiratory system and mediastinum; Antineoplastic agent; Human; Lung disease; Evaluation; Respiratory disease; Treatment efficiency; Docetaxel; Malignant tumor; Bronchopulmonary; Cisplatin; Chemotherapy; Taxane derivatives; Bronchus disease; Survival curve; Comparative study; Non small cell carcinoma; Platinum II Complexes
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2000.18.10.2095

To evaluate whether treatment with single-agent docetaxel would result in longer survival than would best supportive care in patients with non-small-cell lung cancer who had previously been treated with platinum-based chemotherapy. Secondary end points included assessment of response (docetaxel arm only), toxicity, and quality of life.
Patients with performance statuses of 0 to 2 and stage IIIB/IV non-small-cell lung cancer with either measurable or evaluable lesions were eligible for entry onto the study if they had undergone one or more platinum-based chemotherapy regimens and if they had adequate hematology and biochemistry parameters. They were excluded if they had symptomatic brain metastases or if they had previously been treated with paclitaxel. Patients were stratified by performance status and best response to cisplatin chemotherapy and were then randomized to treatment with docetaxel 100 mg/m(2) (49 patients) or 75 mg/m(2) (55 patients) or best supportive care. Patients in both arms were assessed every 3 weeks.
One hundred four patients (103 of whom were eligible for entry onto the study) were well balanced for prognostic factors. Of 84 patients with measurable lesions, six (7. 1%) achieved partial responses (three patients at each dose level). Time to progression was longer for docetaxel patients than for best supportive care patients (10.6 v 6.7 weeks, respectively; P <.001), as was median survival (7.0 v 4.6 months; log-rank test, P =.047). The difference was more significant for docetaxel 75 mg/m(2) patients, compared with corresponding best supportive care patients (7.5 v 4.6 months; log-rank test, P =.010; 1-year survival, 37% v 11%; chi(2) test, P =.003). Febrile neutropenia occurred in 11 patients treated with docetaxel 100 mg/m(2), three of whom died, and in one patient treated with docetaxel 75 mg/m(2). Grade 3 or 4 nonhematologic toxicity, with the exception of diarrhea, occurred at a similar rate in both the docetaxel and best supportive care groups.
Treatment with docetaxel is associated with significant prolongation of survival, and at a dose of 75 mg/m(2), the benefits of docetaxel therapy outweigh the risks.