Induction heating and in vitro cytotoxicity studies of MnZnFe2O4 nanoparticles for self-controlled magnetic particle hyperthermia

• Published in: Journal of alloys and compounds Vol. 745; pp. 282 - 291
• Main Authors: Jadhav, S.V., Kim, B.M., Lee, H.Y., Im, I.C., Rokade, A.A., Park, S.S., Patil, M.P., Kim, G.D., Yu, Y.S., Lee, S.H.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15-05-2018
• Subjects: Colloidal stability; Cytotoxicity; Heating efficiency; MnZnFe2O4; Nanoparticles; Nanoparticles; Cytotoxicity; Heating efficiency; Colloidal stability; MnZnFe2O4
• ISSN: 0925-8388; 1873-4669
• DOI: 10.1016/j.jallcom.2018.02.174

This paper deals with the influence of a biocompatible surface coating layer on the structural, morphological and colloidal and magnetic properties of the MnZnFe2O4 nanoparticles. A series of the MnZnFe2O4 magnetic nanoparticles were synthesized by simple cost-effective co-precipitation technique. Herein, it is found that starch plays an important role in the colloidal stability, dispersibility and the heating efficiency of MNPs. Samples of the resultant magnetic fluid were examined using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), X-ray diffraction (XRD), transmission electron microscopy (TEM), Field emission scanning electron microscopy (FESEM), dynamic light scattering, zeta potential measurements, Vibrating sample magnetometry (VSM) and induction heating studies. The average size of the MnZnFe2O4 and MnZnFe2O4@starch nanoparticles estimated by TEM technique was found to be in the range of 12–15 nm. Magnetometry measurements indicate that superparamagnetic like nature with negligible coercivity and remanence for any of sample. Induction heating efficiency of MnZnFe2O4 nanoparticles under alternating magnetic field was studied by means of specific absorption rate (SAR) measurements, and compared with starch functionalized MnZnFe2O4 nanoparticles. In vitro cytotoxicity on human lung cancer cells studies reveal that tolerable dose rate for MNPs can be significantly high and particles are less toxic in nature. Based on these characterizations of the samples it is suggested that the MnZnFe2O4 ferrites may be a potential candidate for hyperthermia application.
Cell viability Vs Concentration for bare and starch functionalized MnZnFe2O4 MNPs. [Display omitted]
•Surface functionalization of MnZnFe2O4 nanoparticles with starch.•Improved efficiency of magnetic fluid hyperthermia treatment for starch functionalized NPs (also enhanced SAR).•The heating ability observed at low concentration.•Good biocompatibility on human lung carcinoma cells for functionalized MnZnFe2O4@starch nanoparticles.