Effects of exposure to triphenyltin (TPT) contaminant on sperm activity in adulthood of Calomys laucha exposed through breastfeeding

• Published in: Environmental science and pollution research international Vol. 26; no. 8; pp. 8280 - 8288
• Main Authors: de Castro, Tiane Ferreira, Varela Junior, Antônio Sergio, Padilha, Francine Ferreira, Droppa-Almeida, Daniela, Saalfeld, Graciela Quintana, Pires, Diego Martins, Pereira, Jessica Ribeiro, Corcini, Carine Dahl, Colares, Elton Pinto
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2019; Springer Nature B.V
• Subjects: Air quality; Animal reproduction; Animals; Antifouling substances; Aquatic Pollution; Arvicolinae - physiology; Atmospheric Protection/Air Quality Control/Air Pollution; Breast feeding; Breastfeeding & lactation; Contaminants; Earth and Environmental Science; Ecotoxicology; Ecotoxicology - methods; Endocrine disruptors; Endocrine Disruptors - toxicity; Environment; Environmental Chemistry; Environmental Health; Environmental science; Enzymes; Experimental design; Factorization; Female; Kinetics; Lactation; Land use; Male; Motility; Organotin Compounds - toxicity; Particulate matter; Physiology; Pollution; Reproduction - drug effects; Research Article; Sperm; Spermatozoa - drug effects; Spermatozoa - pathology; Tensors; Waste Water Technology; Water Management; Water Pollution Control; Weaning; Triphenyltin; Spermatic kinetics; TPT; Sperm activity; Breastfeeding
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-019-04365-1

Triphenyltin (TPT) is an organotin compound (OT), primarily used in agriculture and in the composition of antifouling paints for ships worldwide. Studies have showed its effects as an endocrine disrupter in several organisms by preventing enzymatic expression and causing reproductive toxicity. This study aimed to evaluate the effects of exposure to TPT, via breastfeeding, on reproductive physiology in the
Calomys laucha
species. The experimental design was compound of five groups, two controls and three with different doses of TPT. Moreover, females were exposed by gavage to the TPT for 20 days, from the 1st day postpartum to the 21st postnatal day (PND). Then, the pups were euthanized and the kinetics, organelles, and biochemistry of the sperm were evaluated. The results presented a reduction in total motility in the groups exposed to TPT. Regarding cellular organelles analysis, a loss in membrane integrity was evidenced; the functionality of mitochondria showed diminution followed by increased acrosome reaction. In conclusion, the TPT causes alteration of the reproductive parameters, decreasing the activity and sperm quality in individuals exposed in the breastfeeding phase.