An evaluation of the effects of probiotics on tumoral necrosis factor (TNF-α) signaling and gene expression

• Published in: Cytokine & growth factor reviews Vol. 57; pp. 27 - 38
• Main Authors: Vincenzi, Angélica, Goettert, Márcia Inês, Volken de Souza, Claucia Fernanda
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-02-2021
• Subjects: Cytokines; Immune system; Inflammation; MAPK; NF-kb; Inflammation; Cytokines; MAPK; NF-kb; Immune system
• ISSN: 1359-6101
• DOI: 10.1016/j.cytogfr.2020.10.004

[Display omitted]
•Probiotics may inhibit phosphorylation of JNK, ERK and p38 MAPKs.•Probiotics may inhibit phosphorilation of IkBs and p65 subunit in the NF-kB pathway.•Probiotics may block the nuclear translocation of AP-1 and NF-kB.
The search for functional foods containing probiotics has been growing due to numerous benefits they provide to health, such as modulation of the immune system and of the anti-inflammatory activity by inhibiting the release of pro-inflammatory cytokines, such as TNF-α. However, the mechanisms of actions of the probiotics responsible for this inhibition have not been completely explained so far. A better understanding of the interaction between probiotics and cell signaling pathways related to inflammatory processes shall help to prevent inflammatory bowel diseases. Therefore, the aim of this revision is to help understand the mechanisms of action of probiotics in cell signaling pathways that regulate TNF-α expression. Probiotics might act at different points of the MAPK pathway, on NF-kB, on proteasome activity, on Toll-like receptors, and on their regulators and stimuli. The present revision reaches the conclusion that probiotics act through multiple mechanisms, especially by inhibiting IkB phosphorylation and degradation, thus preventing the translocation of NF-kB. Effects are also shown to be strain-specific, and probiotics of the genus Lactobacillus are proved to play and essential role in anti-inflammatory activity.