Vat photopolymerization 3D printing for advanced drug delivery and medical device applications

• Published in: Journal of controlled release Vol. 329; pp. 743 - 757
• Main Authors: Xu, Xiaoyan, Awad, Atheer, Robles-Martinez, Pamela, Gaisford, Simon, Goyanes, Alvaro, Basit, Abdul W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10-01-2021
• Subjects: 3D printed drug products; Additive manufacturing; Personalized pharmaceuticals and medicines; Photopolymerisation; Stereolithographic printing; Stereolithography; PEGMA; Personalized pharmaceuticals and medicines; SLA; EPU; 4D; GDMA; Tg; DSC; TPO-L; EMA; PCL-tMa; DMPA; MN; MP2MA; UV; CAD; PCLDMA; UMA; 3D printed drug products; GMP; LCD; 2PP; tBA; ASTM; PCL; DEGDA; PPGDMA; BA; FDA; EDMAB; Photopolymerisation; TPA; UDMA; MRI; PPF; DLP; Additive manufacturing; FDM; CLIP; Stereolithographic printing; TPO; FTIR; PEGDMA; DMD; HPLC; BAPO; CE; DEF; PMA; TMPTA; PEGDA; Stereolithography; CQ; HEMA; 3D; CT; NMR; PEG; SA/V; NIR; LAP; MAOMS; IPA; GRAS
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2020.10.008

Three-dimensional (3D) printing is transforming manufacturing paradigms within healthcare. Vat photopolymerization 3D printing technology combines the benefits of high resolution and favourable printing speed, offering a sophisticated approach to fabricate bespoke medical devices and drug delivery systems. Herein, an overview of the vat polymerization techniques, their unique applications in the fields of drug delivery and medical device fabrication, material examples and the advantages they provide within healthcare, is provided. The challenges and drawbacks presented by this technology are also discussed. It is forecast that the adoption of 3D printing could pave the way for a personalised health system, advancing from traditional treatments pathways towards digital healthcare.
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