Effects of intra-nasally administered testosterone on sexual proceptive behavior in female capuchin monkeys ( Cebus apella)

• Published in: Behavioural brain research Vol. 179; no. 1; pp. 33 - 42
• Main Authors: Tavares, Maria Clotilde, Topic, Bianca, Abreu, Carina, Waga, Isabel, Gomes, Úrsula, Tomaz, Carlos, Mattern, Claudia
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 16-04-2007; Elsevier Science
• Subjects: Administration, Intranasal; Animals; Behavioral psychophysiology; Biological and medical sciences; Cebus; Cebus apella; Dihydrotestosterone - blood; Estradiol - blood; Female; Fundamental and applied biological sciences. Psychology; New world monkeys; Primates; Progesterone - blood; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Sex Factors; Sexual behavior; Sexual Behavior, Animal - physiology; Sexual hormones; Statistics, Nonparametric; Testosterone - administration & dosage; Testosterone - blood; Testosterone - physiology; World; Primates; New world monkeys; Sexual hormones; Sexual behavior; Androgen; Cebus apella; Monkey; Testosterone; Vertebrata; Mammalia; Animal; Simioidea; Female; Testicular hormone; Sex steroid hormone
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2007.01.004

Sexual dysfunction in the female has been associated with a decrease in androgen levels, which can be reversed by testosterone treatment, however, bearing the risk of adverse side effects. Nasally administered testosterone could be an effective method for androgenic treatment avoiding the first-pass intestinal and hepatic metabolism and side effects. Here we examined the effects of chronic intranasal administration of testosterone on sexual behavior in female capuchin monkeys (
Cebus apella) that lived with male cohorts. During 8 days of baseline 10 females were observed for their sexual and non-sexual behavior without drug. They then received daily intranasal testosterone (0.24
mg per nostril,
n
=
5 per group) or placebo gel for 5 days, followed by 5 days of wash out, followed by 5 days of daily intranasal application, whereby the animals that had received testosterone before, now received placebo and
vice versa. Diverse sexual and non-sexual behaviors were scored. Blood samples were collected and analyzed for testosterone, estradiol, dihydrotestosterone and progesterone using EIAs. The results revealed an increase in sexual behavior (eyebrow raising, chest rubbing, courtship behavior, masturbation) in the females during testosterone treatment, which seemed to be prolonged even when testosterone treatment was discontinued. These behavioral results were accompanied by an increase in plasma testosterone levels. This study demonstrates the efficacy of testosterone in enhancing sexual behavior in female capuchin monkeys by means of intranasal application, which may be a useful alternative compared to other forms of administration.