Synthesis and Characterization of Metabolites and Potential Impurities of Lansoprazole, an Antiulcerative Drug

Synthesis and Characterization of Metabolites and Potential Impurities of Lansoprazole, an Antiulcerative Drug

Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger-Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole...

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Bibliographic Details
Published in:Synthetic communications Vol. 38; no. 20; pp. 3477 - 3489
Main Authors: Reddy, Ganta Madhusudhan, Mukkanti, K., Kumar, T. Laxmi, Babu, J. Moses, Reddy, Padi Pratap
Format: Journal Article
Language:English
Published: Taylor & Francis Group 29-09-2008
Subjects:
HR-MS
impurities
lansoprazole
spectral characterization
synthesis
Online Access:Get full text
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Summary:Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger-Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole sulfide, lansoprazole sulfone and N-aralkyl lansoprazole. The present work describes the synthesis and characterization of these impurities.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802162934