Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia

We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age. His low-density lipoprotein cholesterol levels significantly were reduced by adding lomitapide and evi...

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Bibliographic Details
Published in:	JACC. Case reports Vol. 29; no. 12; p. 102367
Main Authors:	Tada, Hayato, Okada, Hirofumi, Kawashiri, Masa-aki, Takamura, Masayuki
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 19-06-2024 Elsevier
Subjects:	Case Report genetic disorders hypercholesterolemia lipid metabolism disorders FH LDLRAPI LDL genetic disorders MTTP ANGPTL3 PCSK9 HoFH LDLR hypercholesterolemia lipid metabolism disorders
Online Access:	Get full text
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Summary:	We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age. His low-density lipoprotein cholesterol levels significantly were reduced by adding lomitapide and evinacumab, and his carotid plaque started to regress. [Display omitted]
ISSN:	2666-0849 2666-0849
DOI:	10.1016/j.jaccas.2024.102367