Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging Fischer 344 rats

• Published in: The Prostate Vol. 16; no. 2; p. 147
• Main Authors: Wilson, M J, Ditmanson, J V, Sinha, A A, Estensen, R D
• Format: Journal Article
• Language: English
• Published: United States 1990
• Subjects: Aging - metabolism; Amiloride - pharmacology; Animals; DNA - metabolism; Male; Peptide Hydrolases - metabolism; Plasminogen Activators - metabolism; Prostate - anatomy & histology; Prostate - metabolism; Proteins - metabolism; Rats; Rats, Inbred F344
• ISSN: 0270-4137
• DOI: 10.1002/pros.2990160206

Plasminogen activator (PA) activities were measured in extracts of ventral and dorsolateral prostate lobes in Fischer 344 (F344) rats of different ages. Ventral prostates of 30-month-old animals demonstrated widespread epithelial atrophy, some foci of inflammation, intraglandular atypical hyperplasia and/or adenocarcinoma, and a marked increase in PA activities compared with younger animals. Both low- and high-molecular-weight forms of activator were found in zymograms and both forms of activator showed an increase at 30 months. However, the PA activity of the aged rats showed a greater resistance to amiloride inhibition, suggesting a greater relative increase in the tissue-type activator activity than that of urokinase. These changes were not observed in the dorsolateral prostate. The lobe-specific changes in activator activity appear related to dysplasia/neoplasia and not aging.