Clinical and Angiographic Outcomes of Drug‐Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion

• Published in: Clinical cardiology (Mahwah, N.J.) Vol. 33; no. 6; pp. 340 - 344
• Main Authors: Kim, Ung, Kim, Dong‐Kie, Seol, Sang‐Hoon, Yang, Tae‐Hyun, Kim, Dae‐Kyung, Kim, Doo‐Il, Kim, Dong‐Soo, Lee, Sang‐Hee, Hong, Geu‐Ru, Park, Jong‐Seon, Shin, Dong‐Gu, Kim, Young‐Jo, Cho, Yoon‐Kyung, Kim, Hyung‐Seop, Nam, Chang‐Wook, Hur, Seung‐Ho, Kim, Kwon‐Bae
• Format: Journal Article
• Language: English
• Published: New York Wiley Periodicals, Inc 01-06-2010; Wiley
• Subjects: Aged; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - instrumentation; Angioplasty, Balloon, Coronary - mortality; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular Agents - administration & dosage; Cardiovascular system; Chi-Square Distribution; Clinical Investigation; Clinical Investigations; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - mortality; Coronary Artery Disease - therapy; Coronary Restenosis - etiology; Disease-Free Survival; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Drug-Eluting Stents; Female; Heart; Hospital Mortality; Hospitals, University; Humans; Investigative techniques, diagnostic techniques (general aspects); Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Myocardial Infarction - etiology; Paclitaxel - administration & dosage; Prosthesis Design; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Republic of Korea; Risk Assessment; Risk Factors; Severity of Illness Index; Sirolimus - administration & dosage; Sirolimus - analogs & derivatives; Thrombosis - etiology; Time Factors; Treatment Outcome; Human; Prognosis; Radiodiagnosis; Angiography; Single coronary artery; Instrumentation therapy; Cardiovascular disease; Patient; Coronary heart disease; Congenital disease; Phlebology; Arterial disease; Vascular disease; Malformation; Circulatory system; Lesion; Cardiology; Drug eluting stent
• ISSN: 0160-9289; 1932-8737
• DOI: 10.1002/clc.20744

Background
The aim of this study was to evaluate and compare the clinical and angiographic outcomes of 3 drug‐eluting stents (DES) in patients with large vessel diameter and single coronary artery lesions.
Hypothesis
The efficacy of 3 DESs may be similar.
Methods
A total of 411 consecutive patients who visited 3 university hospitals from June 2004 to December 2007 and had a single coronary lesion which was treated with the use of a DES that was 3.5 mm in diameter were enrolled in this study. Patients were divided into 3 stent groups: Paclitaxel‐eluting stent (PES, n = 105), Sirolimus‐eluting stent (SES, n = 259), and Zotarolimus‐eluting stent (ZES, n = 47). The study end point was a composite of major adverse cardiac events (MACE) including cardiac death, myocardial infarction (MI), and ischemia‐driven target‐vessel revascularization (TVR) for 12 months.
Results
Baseline characteristics were not different. Late loss was higher in the ZES group than the other stents (0.5 ± 0.4 mm in SES vs 0.3 ± 0.5 mm in PES, 0.7 ± 0.5 mm in ZES, P = 0.001). The total MACE‐free survival rate was not significantly different between the SES group and the PES group (98.8% in SES vs 97.1% in PES, P = 0.252) or the PES group and the ZES group (97.1% in PES vs 93.6% in ZES, P = 0.301). However, the SES group showed a significantly better MACE‐free survival rate compared with the ZES group (98.8% in SES vs 93.6% in ZES, P = 0.018).
Conclusions
Clinical and angiographic outcomes of DES in a large vessel diameter and single coronary artery is excellent and SES appears to show better angiographic and clinical outcomes than ZES. Copyright © 2010 Wiley Periodicals, Inc.