Pulmonary hypertension associated with long-term inhalation of "crank" methamphetamine

We present the case of a 33-year-old white male truck driver with a ten-year history of 3.5-g/wk "crank" and "peanut butter methamphetamine" inhalation (methamphetamine and propylhexedrine, respectively). This patient developed marked pulmonary hypertension as a probable conseque...

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Bibliographic Details
Published in:	Chest Vol. 104; no. 2; p. 614
Main Authors:	Schaiberger, P H, Kennedy, T C, Miller, F C, Gal, J, Petty, T L
Format:	Journal Article
Language:	English
Published:	United States 01-08-1993
Subjects:	Administration, Inhalation Adult Humans Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - diagnosis Male Methamphetamine Propylamines Substance-Related Disorders - complications
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Summary:	We present the case of a 33-year-old white male truck driver with a ten-year history of 3.5-g/wk "crank" and "peanut butter methamphetamine" inhalation (methamphetamine and propylhexedrine, respectively). This patient developed marked pulmonary hypertension as a probable consequence of abuse of these drugs. Proposed mechanisms of disease invoke toxic endothelial injury, hypoxic insult, direct spasm, vasculitis, and dysregulation of mediators of vascular tone. The possible role of genetics is discussed in reference to variability of human response to sympathomimetic challenge.
ISSN:	0012-3692
DOI:	10.1378/chest.104.2.614