Nanofiber-expanded stem cells mitigate liver fibrosis: Experimental study

Highlights • MSCs expanded on nano fibers had prominent effect in the management of liver fibrosis. • MSCs cultured on nanofibers maintained stable gene expression profile and functional biochemistry. • Nanofiber mimiked the natural microenvironment and enhanced proliferation and differentiation of...

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Bibliographic Details
Published in:	Tissue & cell Vol. 48; no. 5; pp. 544 - 551
Main Authors:	Salem, Neveen A, Ahmed, Hanaa H, Aglan, Hadeer A, ElShebiney, Shaimaa A
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01-10-2016
Subjects:	Advanced Basic Science AFP Bcl-2 Cell Differentiation - genetics Cell Movement - drug effects Cell Proliferation - drug effects Hepatocytes - drug effects Humans Intercellular Signaling Peptides and Proteins - therapeutic use Liver - drug effects Liver - growth & development Liver - pathology Liver Cirrhosis - genetics Liver Cirrhosis - pathology Liver Cirrhosis - therapy Liver fibrosis Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Nanofibers - chemistry Nanofibers - therapeutic use Rats Scaffolds TGF-β1 Ultraweb nanofiber Bcl-2 Rats TGF-β1 Ultraweb nanofiber AFP Liver fibrosis Scaffolds Mesenchymal stem cells
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Summary:	Highlights • MSCs expanded on nano fibers had prominent effect in the management of liver fibrosis. • MSCs cultured on nanofibers maintained stable gene expression profile and functional biochemistry. • Nanofiber mimiked the natural microenvironment and enhanced proliferation and differentiation of MSCs.
ISSN:	0040-8166 1532-3072
DOI:	10.1016/j.tice.2016.06.005