Predominance of hepatitis B virus genotype C among Karens, the 'old settlers' of Andaman and Nicobar Islands, India

The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by...

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Bibliographic Details
Published in:	Archives of virology Vol. 152; no. 6; pp. 1223 - 1228
Main Authors:	Datta, S, Chandra, P. K, Banerjee, A, Chakravarty, R, Murhekar, K. M, Murhekar, M. V
Format:	Journal Article
Language:	English
Published:	Wien Vienna : Springer-Verlag 01-06-2007 New York, NY Springer Springer Nature B.V
Subjects:	Adolescent Adult Biological and medical sciences DNA, Viral - genetics Emigration and Immigration Epidemiology Ethnic Groups Evolution, Molecular Female Fundamental and applied biological sciences. Psychology Genes, Viral Genotype & phenotype Hepatitis B Hepatitis B - virology Hepatitis B virus Hepatitis B virus - classification Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Humans India Infections Male Medical research Microbiology Middle Aged Miscellaneous Molecular Sequence Data Mutation Myanmar - ethnology Phylogenetics Phylogeny Polymerase chain reaction Virology Indian Ocean Islands Andaman and Nicobar Asia India Myanmar East Asia Myanmar (Burma) West Bengal India Nicobar Islands Virus Hepadnaviridae Orthohepadnavirus Genotype Hepatitis B virus Flaviviridae Hepatitis C virus Hepacivirus
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Summary:	The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by sequencing and phylogenetic analysis. The predominance of HBV/C1/Cs suggests that they carried HBV during their migration, retained it, and in addition, acquired HBV/D2 from the people of mainland India. The reported association of HBV genotype C with disease severity thus warrants further epidemiological investigations among them and on possible spread among neighboring settlers.
Bibliography:	http://dx.doi.org/10.1007/s00705-006-0910-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-006-0910-0