The antimalarial pipeline – An update

Abstract There are quite a number of antimalarial compounds in different states of preclinical and clinical development. Among those in advanced stages, combinations of known drugs or new substances from drug classes already used in antimalarial therapy are predominant. More compounds with novel or...

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Bibliographic Details
Published in:	International journal of medical microbiology Vol. 302; no. 4; pp. 165 - 171
Main Authors:	Schrader, Florian C, Barho, Marlene, Steiner, Iljana, Ortmann, Regina, Schlitzer, Martin
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01-10-2012
Subjects:	Aminoquinolines - chemistry Aminoquinolines - pharmacology Animals Antimalarials - chemistry Antimalarials - pharmacology Clinical studies Clinical Trials as Topic Drug Combinations Drug development Drug Evaluation, Preclinical Drug Resistance Humans Infectious Disease Inhibitory Concentration 50 Malaria Malaria therapy Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Malaria, Falciparum - prevention & control Medical Education Plasmodium Falciparum Plasmodium falciparum - pathogenicity Malaria therapy Plasmodium Falciparum Malaria Drug development Clinical studies
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Summary:	Abstract There are quite a number of antimalarial compounds in different states of preclinical and clinical development. Among those in advanced stages, combinations of known drugs or new substances from drug classes already used in antimalarial therapy are predominant. More compounds with novel or even unknown mechanism of action are found among those compounds which are in less advanced stages of development.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1438-4221 1618-0607
DOI:	10.1016/j.ijmm.2012.07.009