The roles of the new negative T cell costimulatory pathways in regulating autoimmunity

The B7 family of T cell costimulatory molecules has recently acquired several new members. Some of these are activating while others are inhibitory. In this review, we will focus on the novel inhibitory pathways with particular emphasis on the PD-1:PD-L pathway. Understanding the mechanisms of these...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 20; no. 5; pp. 529 - 538
Main Authors:	Khoury, Samia J, Sayegh, Mohamed H
Format:	Journal Article
Language:	English
Published:	United States Elsevier Limited 01-05-2004
Subjects:	Animals Antigens, Surface - immunology Asthma Autoimmune diseases Autoimmunity B7-1 Antigen - immunology Cell growth Diabetes Disease Humans Immune system Inflammatory bowel disease Ligands Lymphocyte Activation - immunology Lymphocytes Regulation Rodents Signal Transduction - immunology T cell receptors T-Lymphocytes - immunology
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Summary:	The B7 family of T cell costimulatory molecules has recently acquired several new members. Some of these are activating while others are inhibitory. In this review, we will focus on the novel inhibitory pathways with particular emphasis on the PD-1:PD-L pathway. Understanding the mechanisms of these pathways has implications for development of novel treatment strategies for autoimmune disease, transplantation, tumor immunotherapy, and vaccine development.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	1074-7613 1097-4180
DOI:	10.1016/S1074-7613(04)00116-5