Levofloxacin decreased chest wall mechanical inhomogeneities and airway and vascular remodeling in rats with induced hepatopulmonary syndrome

Highlights • Administration of antibiotics decreases bacterial translocation and improves the gas exchange of hepatopulmonary syndrome in rats. • We hypothesized that levofloxacin could reduce respiratory mechanical inhomogeneities and airway and pulmonary vascular remodeling in that. • Levofloxacin...

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Bibliographic Details
Published in:	Respiratory physiology & neurobiology Vol. 189; no. 3; pp. 565 - 570
Main Authors:	Gaio, Eduardo, Amado, Veronica, Rangel, Leonardo, Huang, Wilson, Storck, Rodrigo, Melo-Silva, César Augusto
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2013
Subjects:	Airway remodeling Airway Remodeling - drug effects Airway Remodeling - physiology Animals Cholestasis - complications Disease Models, Animal Hepatopulmonary syndrome Hepatopulmonary Syndrome - complications Hepatopulmonary Syndrome - etiology Hepatopulmonary Syndrome - physiopathology Levofloxacin Levofloxacin - therapeutic use Lung - drug effects Lung - pathology Male Medical Education Membrane Proteins - adverse effects Morphometry Pulmonary Artery - drug effects Pulmonary vascular remodeling Pulmonary/Respiratory Rats Rats, Wistar Respiratory mechanic Respiratory Muscles - drug effects Statistics, Nonparametric Thoracic Wall - drug effects Topoisomerase II Inhibitors - therapeutic use Pulmonary vascular remodeling Levofloxacin Respiratory mechanic Airway remodeling Morphometry Hepatopulmonary syndrome
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