Levofloxacin decreased chest wall mechanical inhomogeneities and airway and vascular remodeling in rats with induced hepatopulmonary syndrome

• Published in: Respiratory physiology & neurobiology Vol. 189; no. 3; pp. 565 - 570
• Main Authors: Gaio, Eduardo, Amado, Veronica, Rangel, Leonardo, Huang, Wilson, Storck, Rodrigo, Melo-Silva, César Augusto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-12-2013
• Subjects: Airway remodeling; Airway Remodeling - drug effects; Airway Remodeling - physiology; Animals; Cholestasis - complications; Disease Models, Animal; Hepatopulmonary syndrome; Hepatopulmonary Syndrome - complications; Hepatopulmonary Syndrome - etiology; Hepatopulmonary Syndrome - physiopathology; Levofloxacin; Levofloxacin - therapeutic use; Lung - drug effects; Lung - pathology; Male; Medical Education; Membrane Proteins - adverse effects; Morphometry; Pulmonary Artery - drug effects; Pulmonary vascular remodeling; Pulmonary/Respiratory; Rats; Rats, Wistar; Respiratory mechanic; Respiratory Muscles - drug effects; Statistics, Nonparametric; Thoracic Wall - drug effects; Topoisomerase II Inhibitors - therapeutic use; Pulmonary vascular remodeling; Levofloxacin; Respiratory mechanic; Airway remodeling; Morphometry; Hepatopulmonary syndrome
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2013.08.006

Highlights • Administration of antibiotics decreases bacterial translocation and improves the gas exchange of hepatopulmonary syndrome in rats. • We hypothesized that levofloxacin could reduce respiratory mechanical inhomogeneities and airway and pulmonary vascular remodeling in that. • Levofloxacin decreased the chest wall mechanical inhomogeneities and airway and vascular remodeling in this syndrome.