The Molten Globule Concept: 45 Years Later

• Published in: Biochemistry (Moscow) Vol. 83; no. Suppl 1; pp. S33 - S47
• Main Authors: Bychkova, V. E., Semisotnov, G. V., Balobanov, V. A., Finkelstein, A. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2018; Springer
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Globular proteins; Life Sciences; Microbiology; Practice; Protein folding; Protein research; Ptitsyn, Oleg Borissovich; Review; Scientists; protein self-organization folding; formation and association of protein secondary structure; free-energy barrier; kinetics of protein folding; molten globule; phase transitions in proteins; Levinthal’s paradox
• ISSN: 0006-2979; 1608-3040
• DOI: 10.1134/S0006297918140043

In this review, we describe traditional systems where the molten globule (MG) state has been detected and give a brief description of the solution of Levinthal’s paradox. We discuss new results obtained for MG-mediated folding of “nontraditional” proteins and a possible functional role of the MG. We also report new data on the MG, especially the dry molten globule.