Effect of β-N-methylamino- l -alanine on oxidative stress of liver and kidney in rat

• Published in: Environmental toxicology and pharmacology Vol. 35; no. 2; pp. 193 - 199
• Main Authors: de Munck, Estefanía, Muñoz-Sáez, Emma, Antonio, María Teresa, Pineda, Javier, Herrera, Amparo, Miguel, Begoña G, Arahuetes, Rosa María
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-03-2013
• Subjects: Amino Acids, Diamino - toxicity; Animals; Antioxidants - metabolism; Catalase - metabolism; Emergency; Female; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Kidney; Kidney - drug effects; Kidney - metabolism; Lipid Peroxidation - drug effects; Liver; Liver - drug effects; Liver - metabolism; Male; Oxidative stress; Oxidative Stress - drug effects; Rats; Rats, Wistar; β-N-methylamino-l-alanine (l-BMAA); β-N-methylamino- l-alanine ( l-BMAA); Oxidative stress; Liver; Kidney; β-N-methylamino-l-alanine (l-BMAA)
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2012.12.004

Highlights ► l -BMAA administration produces oxidative damage in liver and kidney. ► The liver seems to be more susceptible to the l -BMAA toxic action than the kidney. ► Should be noted the increase of lipid peroxidation and high catalase activity. ► Oxidative stress generated in liver and kidney does not compromise the animal's life. ► l -BMAA treated rats can be used to know more about the neurodegenerative diseases events.