An optimal hydrogen-bond surrogate for α-helices

An optimal hydrogen-bond surrogate for α-helices

Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 52; no. 33; p. 5738
Main Authors: Joy, Stephen T, Arora, Paramjit S
Format: Journal Article
Language:English
Published: England 28-04-2016
Subjects:
Hydrogen Bonding
Peptides - chemistry
Protein Conformation
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.
ISSN:1364-548X
DOI:10.1039/c6cc01104g