Photoaffinity inhibition of peptide transport in yeast

A photoaffinity label, 4-azidobenzoyltrimethionine has been synthesized. It competitively inhibits trimethionine uptake in the yeast C. albicans. Upon UV irradiation it irreversibly and specifically blocks oligopeptide uptake. These results give the first example of photoinhibition of peptide uptake...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 110; no. 3; p. 884
Main Authors:	Sarthou, P, Gonneau, M, Le Goffic, F
Format:	Journal Article
Language:	English
Published:	United States 01-01-1983
Subjects:	Affinity Labels - pharmacology Azides - pharmacology Biological Transport - drug effects Candida albicans - drug effects Candida albicans - metabolism Kinetics Oligopeptides - metabolism Photolysis
Online Access:	Get more information
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Summary:	A photoaffinity label, 4-azidobenzoyltrimethionine has been synthesized. It competitively inhibits trimethionine uptake in the yeast C. albicans. Upon UV irradiation it irreversibly and specifically blocks oligopeptide uptake. These results give the first example of photoinhibition of peptide uptake in yeast.
ISSN:	0006-291X
DOI:	10.1016/0006-291X(83)91044-6