Polycaprolactone nanofibers functionalized with a dopamine coating for on-line solid phase extraction of bisphenols, betablockers, nonsteroidal drugs, and phenolic acids

• Published in: Mikrochimica acta (1966) Vol. 186; no. 11; p. 710
• Main Authors: Háková, Martina, Havlíková, Lucie Chocholoušová, Chvojka, Jiří, Erben, Jakub, Solich, Petr, Švec, František, Šatínský, Dalibor
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-11-2019; Springer; Springer Nature B.V
• Subjects: Acids; Adrenergic beta-Antagonists - analysis; Adrenergic beta-Antagonists - isolation & purification; Analytical Chemistry; Anti-Inflammatory Agents, Non-Steroidal - analysis; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Benzoic acid; Biological products; Bisphenol A; Bisphenols; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chlorogenic acid; Chromatography, High Pressure Liquid; Cinnamates - analysis; Cinnamates - isolation & purification; Cinnamic acid; Coated fibers; Coating; Coatings; Dopamine; Drugs; Evaluation; High performance liquid chromatography; Hybrid systems; Indoles - chemistry; Ketoprofen; Meclofenamate; Microengineering; Microfibers; Nanochemistry; Nanofibers; Nanofibers - chemistry; Nanotechnology; Naproxen; On-line systems; Original Paper; Phenolic acids; Phenols; Phenols - analysis; Phenols - isolation & purification; Polycaprolactone; Polyesters - chemistry; Polymerization; Polymers - chemistry; Reproducibility of Results; Rivers - chemistry; Salicylic acid; Sinapic acid; Solid Phase Extraction - methods; Solid phases; Sorbents; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - isolation & purification; Degradation; Solid phase extraction; Surface modification; Microfiber; Column switching; Dopamine coating; Polymerization; Nanofiber; Micro-column; Chromatography
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-019-3846-2

Polycaprolactone composite nanofibers coated with a polydopamine layer are introduced as a new type of absorption material for on-line solid phase extraction (SPE) in chromatographic system. A hybrid technology combining the electrospinning and melt blowing was used for the preparation of 3D-structured microfiber/nanofibrous polycaprolactone composite. The dopamine coating was then applied to functionalize the micro/nanofibers. Polydopamine-coated polycaprolactone fibers were tested as an extraction phase in on-line SPE prior to HPLC separation and UV detection. Four groups of biologically active substances including bisphenols (Bisphenol S, Bisphenol AF, Bisphenol A, Bisphenol C, Bisphenol AP, Bisphenol Z, Bisphenol BP, and Bisphenol M), betablockers (Timolol, Metoprolol, Labetalol, and Propranolol), nonsteroidal antiphlogistic drugs (Salicylic acid, Ketoprofen, Naproxen, Indomethacin, Diclofenac, Ibuprophen, and Meclofenamic acid), and phenolic acids (Chlorogenic acid, Caffeic acid, Sinapic acid, m-Coumaric acid, Benzoic acid, and Cinnamic acid) were used as the model analytes. Neat and coated fibers were compared and applied as sorbents for the on-line extraction set-up. Both materials produced good extraction potential for the determination of bisphenols and nonsteroidal drugs in model biological and environmental samples including river water, human urine, and blood serum. However, the polydopamine layer significantly increased the extraction efficiency of polar drugs. Typical repeatability of on-line extraction procedure on polydopamine coated fibers was in the range 0.12–4.11% for bisphenols, 0.55–1.41% for antiphlogistic drugs, 0.59–2.52% for phenolic acids, and 1.01–1.65% for betablockers.
Graphical abstract
Schematic representation of polycaprolactone composite nanofibers coated with a polydopamine layer as an advanced absorption material for on-line solid phase extraction in chromatography.