IgA Nephropathy Associated with Portal Hypertension in Liver Cirrhosis due to Non-Alcoholic and Non-A, Non-B, Non-C Hepatitis

• Published in: Internal Medicine Vol. 33; no. 8; pp. 488 - 491
• Main Authors: NAKAMURA, Mono, OHISHI, Akira, WATANABE, Reiko, KANEKO, Kohtaro, AOSAKI, Noboru, IIGAYA, Tomohiko, MONMA, Tetsuo, SUGIURA, Hitoshi, MIYOSHI, Yukari, HAMAGUCHI, Kinichi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 1994
• Subjects: Aged; Female; Glomerulonephritis, IGA - etiology; Glomerulonephritis, IGA - pathology; Hepatitis - complications; Hepatitis - pathology; Humans; Hypertension, Portal - drug therapy; Hypertension, Portal - etiology; Hypertension, Portal - pathology; Kidney Glomerulus - ultrastructure; Liver Cirrhosis - etiology; Liver Cirrhosis - pathology; liver disease; mesangial proliferative glomerulonephritis; Microscopy, Electron; Propranolol - therapeutic use; β-blocker
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.33.488

A 69-year-old female was admitted to our hospital because of leg edema, proteinuria (2.1 g/day), and gross hematuria. She had non-alcoholic liver cirrhosis of unknown etiology. Esophageal varices also were found. Examination of the renal biopsy specimen revealed mesangial proliferative glomerulonephritis with IgA deposits. Propranolol was administered orally to reduce portal hypertension, resulting in a progressive decrease in urinary microalbumin excretion. This case suggests that portal hypertension is involved in the pathogenesis of IgA nephropathy in liver cirrhosis. (Internal Medicine 33: 488-491, 1994)