Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole

• Published in: Case reports in gastroenterology Vol. 9; no. 1; pp. 25 - 28
• Main Authors: Goldberg, Neil D., Vadlamudi, Aravinda, Parrish, Nicole
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01-01-2015; Karger Publishers
• Subjects: Combination therapy; Crohnߣs disease; Published: January 2015; Pyoderma gangrenosum; Crohnߣs disease; Combination therapy; Pyoderma gangrenosum; Crohn's disease
• ISSN: 1662-0631; 1662-0631
• DOI: 10.1159/000369965

The etiology of Crohn's disease (CD) remains controversial. It is hypothesized that CD is the result of an abnormal immune response to the gut flora in genetically susceptible hosts. However, an infectious etiology has not been completely ruled out. Antibiotics have been utilized with some success to modify the course of the disease. Here, we report a patient with CD and pyoderma gangrenosum refractory to standard therapy, including biologics, who achieved remission with a combination of rifaximin, gentamicin and metronidazole.