Amniocentesis and chorionic villus sampling in twin gestations: which is the best sampling technique?

• Published in: American journal of obstetrics and gynecology Vol. 202; no. 4; pp. 365.e1 - 365.e5
• Main Authors: Simonazzi, Giuliana, MD, Curti, Alessandra, MD, Farina, Antonio, MD, Pilu, Gianluigi, MD, Bovicelli, Luciano, MD, Rizzo, Nicola, MD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01-04-2010
• Subjects: Adult; amniocentesis; Amniocentesis - adverse effects; Amniocentesis - statistics & numerical data; Chorionic Villi Sampling - adverse effects; Chorionic Villi Sampling - statistics & numerical data; chorionic villus sampling; Cohort Studies; Female; Fetal Death - epidemiology; fetal loss; Fetal Membranes, Premature Rupture - epidemiology; Humans; Kaplan-Meier algorithm; Kaplan-Meier Estimate; Obstetrics and Gynecology; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Retrospective Studies; sampling technique; twin gestation; Twins; sampling technique; amniocentesis; fetal loss; chorionic villus sampling; Kaplan-Meier algorithm; twin gestation
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2009.11.016

Objective To compare the fetal loss rate <24 weeks and the preterm premature rupture of the membranes <34 weeks' gestation according to type of invasive procedure and to sampling techniques in twins. Study Design Retrospective cohort study of 204 twin pregnancies, who underwent amniocentesis (100) or chorionic villus sampling (104). Results Fetal loss rate <4 weeks was 3.85% in chorionic villus sampling group and 4.00% in amniocentesis group ( P value not significant). According to sampling technique, fetal loss rate was 4.17% (chorionic villus sampling 1 puncture), 2.70% (amniocentesis 1 puncture), 3.75% (chorionic villus sampling 2 punctures), and 4.76% (amniocentesis 2 punctures), ( P values not significant). Preterm premature rupture of the membranes rate <34 weeks was 8.2% chorionic villus sampling group and 10% in amniocentesis group ( P value not significant). According to sampling technique, preterm premature rupture of the membranes rate was 12.5% (chorionic villus sampling 1 puncture), 8.1% (amniocentesis 1 puncture), 6.9% (chorionic villus sampling 2 punctures), and 11.1 % (amniocentesis 2 punctures), ( P values not significant). Conclusion Double entry technique does not affect significantly the outcomes evaluated, in both amniocentesis and chorionic villus sampling.