Modification of nucleic acids using [3 + 2]-dipolar cycloaddition of azides and alkynes

The use of azide and alkyne cycloaddition reaction in the synthesis of conjugates of nucleic acids and oligodeoxyribonucleotides is reviewed. Data on the chemical and enzymatic methods for introducing azides and alkynes into DNA are summarized.

Saved in:

Bibliographic Details
Published in:	Russian journal of bioorganic chemistry Vol. 36; no. 4; pp. 401 - 445
Main Authors:	Ustinov, A. V, Stepanova, I. A, Dubnyakova, V. V, Zatsepin, T. S, Nozhevnikova, E. V, Korshun, V. A
Format:	Journal Article
Language:	English
Published:	Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 01-07-2010 SP MAIK Nauka/Interperiodica
Subjects:	alkynes azides Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry cycloaddition Life Sciences modification nucleic acids oligonucleotides Organic Chemistry Review cycloaddition nucleic acids oligonucleotides azides modification alkynes
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The use of azide and alkyne cycloaddition reaction in the synthesis of conjugates of nucleic acids and oligodeoxyribonucleotides is reviewed. Data on the chemical and enzymatic methods for introducing azides and alkynes into DNA are summarized.
Bibliography:	http://dx.doi.org/10.1134/S1068162010040011 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1068-1620 1608-330X
DOI:	10.1134/S1068162010040011