Asymmetric Bromoamination of Chalcones with a Privileged N,N′-Dioxide/Scandium(III) Catalyst

Choice of metal tips: A scandium(III) complex of a chiral N,N′‐dioxide ligand demonstrated excellent regio‐, diastereo‐, and enantioselectivity, as well as exceptionally high activity in the first catalytic asymmetric bromoamination of chalcone derivatives (see picture). The products, α‐bromo‐β‐amin...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 50; no. 34; pp. 7734 - 7736
Main Authors:	Huang, Shao-Xu, Ding, Kuiling
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 16-08-2011 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	asymmetric catalysis bromoamination chalcones N,N′‐dioxides N′-dioxides scandium
Online Access:	Get full text
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Summary:	Choice of metal tips: A scandium(III) complex of a chiral N,N′‐dioxide ligand demonstrated excellent regio‐, diastereo‐, and enantioselectivity, as well as exceptionally high activity in the first catalytic asymmetric bromoamination of chalcone derivatives (see picture). The products, α‐bromo‐β‐amino ketones, have synthetic utility.
Bibliography:	ark:/67375/WNG-QB37L6H1-0 Financial support from the National Natural Science Foundation of China (nos. 20821002, 20923005), the Chinese Academy of Sciences, and the Major Basic Research Development Program of China (grant no. 2010CB833300) is gratefully acknowledged. Chinese Academy of Sciences, and the Major Basic Research Development Program of China - No. 2010CB833300 istex:6CFCD73BA0BDA79B20703B4180B7111FB2D944CE National Natural Science Foundation of China - No. 20821002; No. 20923005 ArticleID:ANIE201101076 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201101076