Stretchable Electrochemical Sensors for Cell and Tissue Detection

• Published in: Angewandte Chemie International Edition Vol. 60; no. 6; pp. 2757 - 2767
• Main Authors: Liu, Yan‐Ling, Huang, Wei‐Hua
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 08-02-2021
• Edition: International ed. in English
• Subjects: Biomolecules; Biosensing Techniques; cells; Chemical sensors; electrochemical sensing; Electrochemical Techniques - instrumentation; Electrochemical Techniques - methods; Electrochemistry; Electrodes; Fabrication; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Mechanotransduction; Mechanotransduction, Cellular; Nanomaterials; Nanostructures - chemistry; Nitric Oxide - analysis; Polymers - chemistry; Sensors; Soft tissues; stretchable electrodes; Tissues; Umbilical Veins - metabolism; electrochemical sensing; cells; stretchable electrodes; tissues; mechanotransduction
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.202007754

Electrochemical sensing based on conventional rigid electrodes has great restrictions for characterizing biomolecules in deformed cells or soft tissues. The recent emergence of stretchable sensors allows electrodes to conformally contact to curved surfaces and perfectly comply with the deformation of living cells and tissues. This provides a powerful strategy to monitor biomolecules from mechanically deformed cells, tissues, and organisms in real time, and opens up new opportunities to explore the mechanotransduction process. In this minireview, we first summarize the fabrication of stretchable electrodes with emphasis on the nanomaterial‐enabled strategies. We then describe representative applications of stretchable sensors in the real‐time monitoring of mechanically sensitive cells and tissues. Finally, we present the future possibilities and challenges of stretchable electrochemical sensing in cell, tissue, and in vivo detection.
Emerging stretchable electrodes open up new opportunities for the real‐time monitoring of biomolecule release from deformed cells, soft tissues, and organisms. In this minireview, we summarize recent advances in the fabrication of stretchable electrochemical sensors and their representative applications in cell, tissue, and in vivo detection.