Preliminary experience with gemcitabine and cisplatin adjuvant chemotherapy after liver transplantation for hepatocellular carcinoma

• Published in: European journal of surgical oncology Vol. 34; no. 8; pp. 906 - 910
• Main Authors: Hsieh, C.-B, Chou, S.-J, Shih, M.-L, Chu, H.-C, Chu, C.-H, Yu, J.-C, Yao, N.-S
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-08-2008
• Subjects: Antineoplastic Agents - therapeutic use; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - surgery; Chemotherapy, Adjuvant; Cisplatin - therapeutic use; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Disease-Free Survival; Disease-free survival rate; Disease-specific survival rate; Female; Gemcitabine; Hematology, Oncology and Palliative Medicine; Hepatocellular carcinoma; Humans; Immunosuppressive Agents - therapeutic use; Liver Neoplasms - drug therapy; Liver Neoplasms - surgery; Liver Transplantation; Male; Middle Aged; Milan criteria; Surgery; Treatment Outcome; Milan criteria; Hepatocellular carcinoma; Disease-specific survival rate; Gemcitabine; Disease-free survival rate; Liver transplantation
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2007.11.014

Abstract Aim Liver transplantation (LT) criteria for treatment of hepatocellular carcinoma (HCC) were refined to improved survival and disease-free rates. Adjuvant chemotherapy might eliminate disseminated tumor cells after removal of the primary liver cancer and thereby benefit LT recipients. Our purpose was to evaluate the effect of an adjuvant chemotherapy (gemcitabine and cisplatin) on outcome of patients treated with LT for HCC. Methods Of the 99 patients who underwent liver transplantation from October 2001 through February 2006, there were 58 with HCC. Nine patients with extra-hepatic metastasis and four who died for noncancer-related reasons were excluded. Three groups (total n = 45) were compared: Group A ( n = 15) met the Milan criteria and did not receive study chemotherapy, Group B ( n = 13) did not fit the Milan criteria and did not receive chemotherapy, and Group C ( n = 17) did not fit the Milan criteria and received gemcitabine and cisplatin. Results The chemotherapy regimen was well tolerated. Leukopenia, the need for granulocyte colony-stimulating factor treatment, or both occurred in four patients. The disease-specific survival rates were better for groups A and C than for group B ( p = 0.02) and the disease-free survival rates were also better for groups A and C than for group B ( p = 0.01). Conclusions Systemic gemcitabine and cisplatin may improve disease-specific and disease-free survival in HCC patients who do not meet the Milan criteria after LT.