Spectrophotometric determination of cefaclor in pharmaceutical preparations

Spectrophotometric determination of cefaclor in pharmaceutical preparations

A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentratio...

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Bibliographic Details
Published in:Química nova Vol. 22; no. 2; pp. 201 - 204
Main Authors: Ivama, Viviane M., Rodrigues, Letícia N. C., Guaratini, Cláudia C. I., Zanoni, Maria Valnice B.
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Química 01-04-1999
Subjects:
cefaclor
hydrolysis
pharmaceuticals
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Summary:A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm. Beer's law is obeyed in the concentration range 1.8 - 55 mg/mL. The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40421999000200011