A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities

A Review on the Green Synthesis of Benzimidazole Derivatives and Their Pharmacological Activities

Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic...

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Bibliographic Details
Published in:Catalysts Vol. 13; no. 2; p. 392
Main Authors: Monica Nardi, Natividad Carolina Herrera Cano, Svilen Simeonov, Renata Bence, Atanas Kurutos, Rosa Scarpelli, Daniel Wunderlin, Antonio Procopio
Format: Journal Article
Language:English
Published: MDPI AG 01-02-2023
Subjects:
benzimidazole
green chemistry
pharmacological activity
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Summary:Benzimidazoles and their derivatives play an extraordinarily significant role as therapeutic agents, e.g., antiulcer, analgesic, and anthelmintic drugs. The organic synthesis of benzimidazoles and derivatives to obtain active pharmacological compounds represents an important research area in organic chemistry. The use of non-environmental organic compounds and application high energy synthetic methods, the production of waste, and the application of conventional toxic processes are a problem for the pharmaceutical industry and for these important drugs’ synthesis. The substituted benzimidazoles are summarized in this review to provide insight about their organic synthesis using ecofriendly methods, as well as their pharmacological activities.
ISSN:2073-4344
DOI:10.3390/catal13020392