Gold Activation of Nitriles: Catalytic Hydration to Amides

Gold Activation of Nitriles: Catalytic Hydration to Amides

Innocence lost: The unprecedented gold‐mediated activation of nitriles is reported. A [(NHC)AuI]‐based catalytic system was found to be efficient for the nitrile hydration reaction of a broad spectrum of substrates that includes aromatic, heteroaromatic, and aliphatic examples.

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Bibliographic Details
Published in:Chemistry : a European journal Vol. 15; no. 35; pp. 8695 - 8697
Main Authors: Ramón, Rubén S., Marion, Nicolas, Nolan, Steven P.
Format: Journal Article
Language:English
Published: Weinheim WILEY‐VCH Verlag 07-09-2009
Subjects:
amides
gold
hydration
nitriles
N‐heterocyclic carbenes
Online Access:Get full text
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Description
Summary:Innocence lost: The unprecedented gold‐mediated activation of nitriles is reported. A [(NHC)AuI]‐based catalytic system was found to be efficient for the nitrile hydration reaction of a broad spectrum of substrates that includes aromatic, heteroaromatic, and aliphatic examples.
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ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200901231