Reduction of intrapulmonary shunt and resolution of digital clubbing associated with primary biliary cirrhosis after liver transplantation

This report describes a patient with marked hypoxemia caused by intrapulmonary shunt associated with primary biliary cirrhosis. Liver transplantation resulted in resolution of digital clubbing and reduction of intrapulmonary shunt as demonstrated by normalization of room air arterial blood gases, re...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 11; no. 1; p. 54
Main Authors:	Stoller, J K, Moodie, D, Schiavone, W A, Vogt, D, Broughan, T, Winkelman, E, Rehm, P K, Carey, W D
Format:	Journal Article
Language:	English
Published:	United States 01-01-1990
Subjects:	Adult Arteriovenous Fistula - surgery Female Humans Hypoxia - etiology Hypoxia - surgery Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - surgery Liver Transplantation Osteoarthropathy, Secondary Hypertrophic - etiology Osteoarthropathy, Secondary Hypertrophic - surgery Pulmonary Artery Pulmonary Circulation Pulmonary Veins
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Summary:	This report describes a patient with marked hypoxemia caused by intrapulmonary shunt associated with primary biliary cirrhosis. Liver transplantation resulted in resolution of digital clubbing and reduction of intrapulmonary shunt as demonstrated by normalization of room air arterial blood gases, reduction in shunt fraction and normalization of the indocyanine-enhanced echocardiogram and perfusion lung scan. This patient's course challenges the conventional notion that intrapulmonary shunting associated with chronic liver disease does not reverse after liver transplantation.
ISSN:	0270-9139
DOI:	10.1002/hep.1840110111