Changes in Liver Graft Rejections Over Time

• Published in: Transplantation proceedings Vol. 38; no. 8; pp. 2663 - 2666
• Main Authors: Matinlauri, I.H., Nurminen, M.M., Höckerstedt, K.A., Isoniemi, H.M.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-10-2006; Elsevier Science
• Subjects: ABO Blood-Group System; Adolescent; Adult; Aged; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - epidemiology; Histocompatibility Testing; Humans; Immunosuppression - adverse effects; Liver Diseases - classification; Liver Diseases - surgery; Liver Transplantation - immunology; Liver Transplantation - pathology; Male; Medical sciences; Middle Aged; Postoperative Complications - epidemiology; Retrospective Studies; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Medicine; Rejection; Graft(material); Treatment; Digestive system; Surgery; Liver; Graft; Time; Transplantation; Change; Homotransplantation
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2006.07.032

Incidence and possible risk factors of acute rejection, time to acute rejection, graft rejection within 3 months, multiple rejections within 1 year, steroid-resistant rejection, and graft lost to chronic rejection or to chronic dysfunction were evaluated in 388 liver transplantations. HLA matches, anti-HLA class I antibodies, positive crossmatch test, or positive cytomegalovirus serology did not have an effect on the occurrence of acute or chronic rejection. Increased total bleeding diminished occurrence of acute rejection, lengthened the time to acute rejection, and reduced the risk of steroid-resistant rejection. Immunological pretransplant factors did not have a major effect on the occurrence of rejection after liver transplantation. Different types of rejections diminished over time and the time period to the first acute rejection increased, although the basic immunosuppression stayed mainly the same over 20 years in our center.