Muscle MRI in Duchenne muscular dystrophy: Evidence of a distinctive pattern

• Published in: Neuromuscular disorders : NMD Vol. 26; no. 11; pp. 768 - 774
• Main Authors: Polavarapu, Kiran, Manjunath, Mahadevappa, Preethish-Kumar, Veeramani, Sekar, Deepha, Vengalil, Seena, Thomas, PriyaTreesa, Sathyaprabha, Talakad N, Bharath, Rose Dawn, Nalini, Atchayaram
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01-11-2016
• Subjects: Adipose Tissue - diagnostic imaging; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Duchenne muscular dystrophy; Humans; Image Interpretation, Computer-Assisted; Lower Extremity - diagnostic imaging; Magnetic Resonance Imaging; Muscle imaging; Muscle, Skeletal - diagnostic imaging; Muscular Dystrophy, Duchenne - diagnostic imaging; Neurology; Phenotype; Prospective Studies; Severity of Illness Index; Magnetic resonance imaging; Muscle imaging; Duchenne muscular dystrophy
• ISSN: 0960-8966; 1873-2364
• DOI: 10.1016/j.nmd.2016.09.002

Highlights • Consistent pattern of muscle involvement on MRI of lower limbs in DMD. • Gluteus medius, minimus and adductor magnus were severely affected at all stages. • Fatty infiltration showed negative correlation with modified MRC grading. • Fatty infiltration showed negative correlation with MDFRS scores. • Myoedema and fatty infiltration showed inverse relation in thigh muscles.