Immune status does not predict high-risk HPV in anal condyloma

• Published in: The Journal of surgical research Vol. 201; no. 1; pp. 166 - 169
• Main Authors: Lee, Janet T., MD, MS, Goldberg, Stanley M., MD, Madoff, Robert D., MD, Tawadros, Patrick S., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-03-2016
• Subjects: Adolescent; Adult; Aged; Anal condyloma; Anus Neoplasms - immunology; Anus Neoplasms - virology; Condylomata Acuminata - immunology; Condylomata Acuminata - virology; Dysplasia; Female; Genital warts; HPV; Humans; Immunocompromised Host; Male; Middle Aged; Papillomaviridae - genetics; Precancerous Conditions - immunology; Precancerous Conditions - virology; Retrospective Studies; Surgery; Young Adult; Genital warts; Dysplasia; Anal condyloma; HPV
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1016/j.jss.2015.10.027

Abstract Background More than 90% of anal condyloma is attributed to nonhigh risk strains of human papillomavirus (HPV), thus patients with anal condyloma do not necessarily undergo HPV serotyping unless they are immunocompromised (IC). We hypothesized that IC patients with anal condyloma have a higher risk of high-risk HPV and dysplasia than nonimmunocompromised (NIC) patients. Methods We performed a retrospective chart review of patients who underwent surgical treatment by a single surgeon for anal condyloma from 1/2000 to 1/2012. HPV serotyping was performed on all patient samples. We compared incidence of high-risk HPV and dysplasia in condyloma specimens from IC and NIC patients. Results High-risk HPV was identified in 14 specimens with serotypes 16, 18, 31, 33, 51, 52, and 67. Twenty-two cases (18.3%) had dysplasia. Invasive carcinoma was identified in one IC patient. The prevalence of dysplasia or high-risk HPV was not significantly different between IC and NIC groups. High-risk HPV was a significant independent predictor of dysplasia (odds ratio [OR] = 5.2; 95% CI = 1.24–21.62). Immune status, however, was not a significant predictor of high-risk HPV (OR = 1.11; 95% CI = 0.16–5.12) nor dysplasia (OR = 0.27; 95% CI = 0.037–1.17). Conclusions IC patients did not have a significantly higher prevalence or risk of high-risk HPV or dysplasia in our study. HPV typing of all condylomata, regardless of immune status, should be considered as it may help predict risk of neoplastic transformation or identify NIC patients with an increased risk of developing anal intraepithelial neoplasia.