CAP1 expression is developmentally regulated in Xenopus

• Published in: Mechanisms of development Vol. 113; no. 2; pp. 211 - 214
• Main Authors: KhosrowShahian, F., Hubberstey, A.V., Crawford, M.J.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-05-2002
• Subjects: act up; Animals; Branchial arch; CAP1; Cell Cycle Proteins - biosynthesis; Cell Cycle Proteins - genetics; Cloning, Molecular; Cyclase associated protein; Cytoskeletal Proteins; Drosophila Proteins; Eye - embryology; Gene Expression Regulation, Developmental; In Situ Hybridization; Lens; Microfilament Proteins; Ocular mesenchyme; Pronephros; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Sensorial ectoderm; Serine Endopeptidases; Time Factors; Up-Regulation; Xenopus; Xenopus laevis; Xenopus Proteins; CAP1; Cyclase associated protein; Ocular mesenchyme; Xenopus laevis; Sensorial ectoderm; Branchial arch; act up; Lens; Pronephros
• ISSN: 0925-4773; 1872-6356
• DOI: 10.1016/S0925-4773(02)00033-3

We have cloned and characterized a
Xenopus member of the
cyclase associated protein (
CAP) gene family.
xCAP1 is expressed as a maternal transcript, but is up-regulated prior to gastrulation and subsequently localizes to head mesenchyme, lens, otic vesicle, and trunk mesoderm including the pronephros. At different stages, the gene also appears to differentiate surface from deep (sensorial) ectoderm. As in
Drosophila,
Xenopus CAP1 is expressed in the developing eye, specifically in the differentiating lens. However, in distinction to
Drosophila,
Xenopus CAP1 does not express in periodically arrayed neural bands.