Low-Grade Glioma Radiotherapy Treatment and Trials

Low-Grade Glioma Radiotherapy Treatment and Trials

Low-grade gliomas represent an important class of primary brain tumors. They account for approximately 20% of primary brain tumors and typically present in the fourth decade of life. Standard management gliomas involves observation, surgery, chemotherapy, and/or radiotherapy. Treatment decisions are...

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Bibliographic Details
Published in:Neurosurgery clinics of North America Vol. 30; no. 1; pp. 111 - 118
Main Authors: Wang, Tony J.C., MD, Mehta, Minesh P., MD
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-01-2019
Subjects:
Brain Neoplasms - pathology
Brain Neoplasms - radiotherapy
Clinical Trials as Topic
Glioma - pathology
Glioma - radiotherapy
Humans
Low-grade glioma
Neoplasm Grading
Neurosurgery
Progression-Free Survival
Radiotherapy
Trials
Radiotherapy
Trials
Low-grade glioma
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Description
Summary:Low-grade gliomas represent an important class of primary brain tumors. They account for approximately 20% of primary brain tumors and typically present in the fourth decade of life. Standard management gliomas involves observation, surgery, chemotherapy, and/or radiotherapy. Treatment decisions are based on many factors including prognostic molecular markers, potential benefits of increased progression-free survival, and potential long-term treatment complications. Recent studies have improved our understanding regarding therapeutic interventions. This review provides an overview of low-grade glioma and discusses the roles of radiation therapy. We discuss advances in techniques and recent and ongoing radiation therapy-related clinical trials for low-grade gliomas.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1042-3680
1558-1349
DOI:10.1016/j.nec.2018.08.008