Effect of fluorogestone acetate on embryo recovery and quality in eCG-superovulated goats with premature luteal regression

• Published in: Theriogenology Vol. 62; no. 3-4; pp. 624 - 630
• Main Authors: Espinosa-Márquez, M.C, Valencia, J, Zarco, L, Escobar-Medina, F.J, Colina-Flores, F, Arechiga-Flores, C.F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-08-2004
• Subjects: Administration, Intravaginal; Animals; Breeding; Chorionic Gonadotropin - administration & dosage; Corpus luteum; eCG; embryo (animal); Embryo, Mammalian - physiology; equine chorionic gonadotropin; Female; FGA; Flurogestone Acetate - administration & dosage; Goats; luteolysis; Luteolysis - drug effects; Pregnancy; Premature luteolysis; progestational hormones; progesterone; Superovulation; Time Factors; Tissue and Organ Harvesting - veterinary; eCG; Corpus luteum; FGA; Goats; Premature luteolysis; Superovulation
• ISSN: 0093-691X; 1879-3231
• DOI: 10.1016/j.theriogenology.2004.01.001

The objective of this study was to evaluate if treatment of eCG-superovulated goats with fluorogestone acetate (FGA) would increase the number and quality of embryos recovered. Goats (n=25) were given an intravaginal sponge containing 45mg FGA for 12 days, with 1000IU eCG and 7.5mg of Luprostiol (a PGF2α analog) given −48 and 0h relative to sponge removal. Goats were mated by natural service every 12h during estrus and surgical embryo collection was done 6 days after the last mating. There were two treatment groups; those in the FGA group (n=13) had a FGA sponge from 8h after mating to embryo collection, whereas goats in the control group (n=12) did not receive any post-mating treatment. Premature luteal regression occurred in 61.5% (8/13) and 83.3% (10/12) of the goats in the FGA and the control groups, respectively (P>0.05). Corpus luteum life span averaged 4 days in goats with premature luteolysis. The mean (±S.E.) number of transferable embryos was 5.7±1.6 in the FGA group and 0.1±0.1 in the control group (P<0.05). Within the FGA group, the embryo recovery rate was similar in goats with premature luteal regression compared to those with normal luteal function, although non-transferable embryos were only found in goats with premature luteal regression. In conclusion, post-breeding treatment with FGA increased embryonic survival in eCG-superovulated goats, even though it did not prevent premature luteal regression.