Incorporation of the chemotherapy medication cisplatin into polyamide membrane

• Published in: Journal of inorganic biochemistry Vol. 180; pp. 171 - 178
• Main Authors: de Souza, Érica A., Rocha, Lucas A., de Faria, Emerson H., Ciuffi, Katia J., Nassar, Eduardo J., Silva, Jorge V.L., Oliveira, Marcelo F., Maia, Izaque A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-03-2018
• Subjects: Additive manufacturing; Cytotoxicity; Functionalization; Sol–gel; Cytotoxicity; Additive manufacturing; Functionalization; Sol–gel
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2017.12.013

The search for more efficient and less aggressive cancer treatment methods has intensified over the last decades and has involved many scientific areas. To provide skin cancer patients with better quality of life, this work aims to incorporate chemotherapy into polyamide membranes, functionalized by the sol–gel methodology, for controlled drug release at the target tissue. A 200-micrometer-thick flexible polyamide membrane prepared by Additive Manufacture was activated and functionalized with the alkoxide 3-chloropropyltriethoxysilane, which was followed by incorporation of the antitumor agent cisplatin. Membrane functionalization with the alkoxide was attested by infrared absorption spectroscopy, which evidenced a band at 1100cm−1, due to Si-O-Si vibration, and typical cisplatin bands at 3200 and 1600cm−1. The thermogravimetric curve revealed increased silicon oxide and platinum residues. Drug release was tested in simulated body fluid. Cytotoxicity was evaluated by the Cell Proliferation Kit, which gave IC50 of 23.95μgM.
The article describes the incorporation of the chemotherapy medication onto polyamide membrane obtained by Additive Manufacture. This work presents potential applications against skin cancer by drug delivery system directly on target. The Additive Manufacture is an important technology to prepare different form and size of the polymeric membrane. [Display omitted]
•A new drug delivery system to chemotherapy cisplatin•Manufacture Additive as tools to prepare the polyamide membrane•The sol-gel methodology is an efficient process to modify the polyamide surface.