Endothelial progenitor cells dysfunction and impaired tissue reparation: The missed link in diabetes mellitus development

• Published in: Diabetes & metabolic syndrome clinical research & reviews Vol. 11; no. 3; pp. 215 - 220
• Main Author: Berezin, Alexander E., MD, PhD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-07-2017
• Subjects: Angiogenesis; Animals; Cardiovascular complications; Diabetes mellitus; Diabetes Mellitus - etiology; Diabetes Mellitus - pathology; Diabetes Mellitus - physiopathology; Disease Progression; Endocrinology & Metabolism; Endothelial progenitor cells; Endothelial Progenitor Cells - pathology; Endothelial Progenitor Cells - physiology; Humans; Reparation; coronary artery disease; NADPH; NO; T2DM; peripheral blood-derived endothelial progenitor cells; RAAS; SDF-1; DM; HP1α; diabetes mellitus; NF-kappaB; granulocyte colony-stimulating factor; advanced glycation end products; HIF-1; heterochromatin protein 1α; Angiogenesis; endothelial progenitor cells; reactive oxidative species; type 2 diabetes mellitus; HUVEC; EPCs; PB-EPCs; Reparation; AGE; bone marrow-derived endothelial progenitor cells; nitric oxide; BM-EPCs; nicotinamide-adenine dinucleotide phosphate; VEGF; CAD; MMPs; metalloproteinases; PKC; cardiovascular; chemokine stromal cell-derived factor-1; G-CSF; Cardiovascular complications; CV; vascular endothelial growth factor; hypoxia-inducible factor-1; human umbilical vein endothelial cells; ROS; activation of protein kinase C; nuclear factor kappaB; the renin-angiotensin-aldosterone system; Endothelial progenitor cells; Diabetes mellitus
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2016.08.007

Abstract Diabetes mellitus (DM) is considered a leading cause of premature cardiovascular (CV) mortality and morbidity in general population and in individuals with known CV disease. Recent animal and clinical studies have shown that reduced number and weak function of endothelial progenitor cells (EPCs) may not only indicate to higher CV risk, but contribute to the impaired heart and vessels reparation in patients with DM. Moreover, EPCs having a protective impact on the vasculature may mediate the functioning of other organs and systems. Therefore, EPCs dysfunction is probably promising target for DM treatment strategy, while the role of restoring of EPCs number and functionality in CV risk diminish and reduce of DM-related complications is not fully clear. The aim of the review is summary of knowledge regarding EPCs dysfunction in DM patients.