Understanding and Treating Fatigue in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

• Published in: Clinics in liver disease Vol. 20; no. 1; pp. 131 - 142
• Main Authors: Jopson, Laura, MBChB, Dyson, Jessica K., MBBS, Jones, David E.J., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-02-2016
• Subjects: Animals; Autonomic Nervous System - physiopathology; Central Nervous System - physiopathology; Cholangitis, Sclerosing - complications; Cholestasis; Fatigue; Fatigue - diagnosis; Fatigue - etiology; Fatigue - physiopathology; Fatigue - therapy; Gastroenterology and Hepatology; Humans; Liver Cirrhosis, Biliary - complications; Models, Theoretical; Primary biliary cirrhosis; Primary sclerosing cholangitis; Quality of life; Severity of Illness Index; Primary biliary cirrhosis; Fatigue; Primary sclerosing cholangitis; Cholestasis; Quality of life
• ISSN: 1089-3261; 1557-8224
• DOI: 10.1016/j.cld.2015.08.007

Fatigue is a significant problem for patients with primary biliary cirrhosis and although experienced less by patients with primary sclerosing cholangitis, a minority still report significant fatigue. Fatigue is the symptom with the greatest impact on quality of life, particularly when associated with social dysfunction. The pathogenesis of fatigue in cholestatic liver disease is complex, poorly understood, and probably has central and peripheral components. Managing fatigue in cholestatic liver disease presents a challenge for clinicians given the complexity and its numerous associations. This article presents a structured approach to managing fatigue in cholestatic liver disease to improve fatigue severity and quality of life.