DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

• Published in: Nutrition, metabolism, and cardiovascular diseases Vol. 30; no. 1; pp. 56 - 59
• Main Authors: Makarewicz-Wujec, Magdalena, Henzel, Jan, Kruk, Mariusz, Kępka, Cezary, Wardziak, Łukasz, Trochimiuk, Piotr, Parzonko, Andrzej, Demkow, Marcin, Kozłowska-Wojciechowska, Małgorzata
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 03-01-2020
• Subjects: Atherosclerosis; Chemokine CXCL4; DASH diet; Inflammation; Inflammation; Chemokine CXCL4; Atherosclerosis; DASH diet
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2019.07.013

Aim of this study involved assessment of the intensive intervention concerning lifestyle based on the DASH diet model on plasma concentration of CXCL4 chemokine among patients with coronary atherosclerosis.
The Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography Study randomized patients with stable CAD to an interventional group (n = 41), where DASH diet was implemented and the control group (n = 40) without dietary intervention. Dietary counselling was provided to DASH group during all 6 control visits within 6 months of observation. During the study, body weight and body composition were controlled using the bioimpedance method. CXCL4 concentration was determined with the use of ELISA test.
Within the DASH group, a significant decrease in body weight, a decrease in high sensitivity C-reactive protein concentration (−0.32 ± 2.8 mg/l; p < 0.05), as well as a decrease in CXCL4 concentration (−3.35 ± 3.4 ng/ml; p < 0.0001) were observed. Occurring changes were not statistically significant within the control group.
DASH diet lessens CXCL4 concentration among patients with a stable CAD, however, further research is necessary in order to confirm aforementioned results and evaluate the impact on atherosclerotic plaque.
www.clinicaltrials.gov as NCT02571803.
•DASH diet in patients with atherosclerotis decreases CRP and CXCL4 plasma level.•CXCL4 concentration in DASH group correlates inversely with DASH index for vegetables.•There is a need for further research on CXCL4 as a therapeutic target.