Long-Term Outcome of Cadaveric Pediatric En Bloc Transplantation — A 15-Year Experience

• Published in: Transplantation proceedings Vol. 37; no. 10; pp. 4228 - 4229
• Main Authors: Smyth, G.P., Eng, M.P., Power, R.P., Hickey, D.P., Little, D.M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-12-2005; Elsevier Science
• Subjects: Adult; Aged; Biological and medical sciences; Cadaver; Cause of Death; Child; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glomerular Filtration Rate; Humans; Immunosuppression - methods; Kidney Transplantation - methods; Kidney Transplantation - mortality; Kidney Transplantation - physiology; Male; Medical sciences; Middle Aged; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Time Factors; Tissue Donors - statistics & numerical data; Tissue, organ and graft immunology; Treatment Outcome; Human; Pediatrics; Prognosis; Transplantation; Homotransplantation; Long term; Medicine; Experience; Treatment; Surgery; Evolution; Graft; Child; Cadaver
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2005.11.019

Pediatric en bloc transplantation of infant organs into adult recipients is a recognized technique to expand the number of kidneys available for transplantation. We reviewed our experience with this technique over a 15-year period to determine the long-term outcomes. Twelve patients underwent pediatric en bloc transplantation from donors aged <4 years. All transplants functioned immediately with no graft thrombosis. Two patients died 12 and 10 years posttransplant with functioning grafts. The remaining 10 recipients experienced excellent graft function with a mean follow-up time of 73.8 months (range, 10 to 169 months) with no evidence of hyperfiltration injury. We conclude that pediatric en bloc transplantations achieve excellent long-term allograft function in selected recipients.