Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview

• Published in: Microbes and infection Vol. 19; no. 1; pp. 47 - 54
• Main Authors: Sharma, Drashya, Yagnik, Bhrugu, Baksi, Ruma, Desai, Nirav, Padh, Harish, Desai, Priti
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-01-2017
• Subjects: Administration, Oral; Animals; Comparative; Disease Models, Animal; Dysentery, Bacillary - microbiology; Dysentery, Bacillary - pathology; Female; Injections, Intraperitoneal; Intranasal; Intraperitoneal; Mice, Inbred BALB C; Murine model; Pathophysiology; Shigella flexneri - pathogenicity; Shigellosis; Intraperitoneal; Intranasal; Pathophysiology; Shigellosis; Comparative; Murine model
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/j.micinf.2016.09.002

Shigellosis, a major cause of mortality and morbidity, requires development of effective intervention strategy for which animal model mimicking human pathology is essential. Among various animal models for shigellosis, mice being more convenient have been used wherein intraperitoneal and intranasal routes are preferred. With the aim to comprehend the comparative pathophysiological indicators, we have examined relatively high and low dose of Shigella flexneri administered through intraperitoneal and intranasal routes in mice. Characterization of these two models along with the resulting pathophysiology of shigellosis adds to our understanding and offers suitable models appropriate to the objectives of the study.